Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control,...

Area of Science:

• Immunology
• Metabolic research
• Nutritional science

Background:

• Psoriasis is a chronic inflammatory condition linked to metabolic and cardiovascular diseases.
• Dietary interventions like intermittent fasting show promise, but their effects independent of weight loss are unclear.
• Time-restricted eating (TRE) offers high adherence and may improve immune function in metabolic syndrome.

Purpose of the Study:

• To evaluate the effects of short-term, isocaloric TRE on immune cell function and serum metabolites in psoriasis patients.
• To compare these effects between individuals with mild-to-moderate psoriasis and healthy controls, independent of weight loss.

Main Methods:

• A case-control, prospective study involving 10 healthy males and 10 age-, BMI-, and sex-matched males with mild-to-moderate psoriasis.
• Participants underwent 3 days of TRE with a 6-hour eating window and 18-hour fast.
• Immune profiles, glucose handling, energy expenditure, and weight were assessed at baseline and post-intervention.

Main Results:

• Data analysis is ongoing, with multiomic datasets being generated from blood and serum samples.
• Gene expression, protein levels, and metabolite profiles are being analyzed.
• Integrated bioinformatics analyses will be reported upon completion of data analysis.

Conclusions:

• This study protocol aims to characterize TRE's effects on psoriasis, focusing on immune cell responses independent of weight loss.
• The research will map TRE-activated molecular pathways influencing immune cell composition, activation, and metabolism.
• Findings may enhance understanding of psoriasis pathogenesis and identify new therapeutic strategies.