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Metabolic States of the Body: Fasting and Starvation01:24

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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Intermittent fasting and longevity: From animal models to implication for humans.

Olha Strilbytska1, Svitlana Klishch1, Kenneth B Storey2

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Intermittent fasting (IF) offers a non-drug approach to combat aging and extend lifespan. This dietary strategy optimizes energy use, improving healthspan and potentially preventing diseases.

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Area of Science:

  • Metabolic Health
  • Longevity Science
  • Nutritional Neuroscience

Background:

  • Intermittent fasting (IF) is gaining recognition as a therapeutic strategy for age-related conditions and lifespan extension.
  • Varied IF schedules share common physiological mechanisms, including metabolic switching from glucose to fatty acids and ketones.
  • Optimized energy utilization is a key factor in the beneficial effects of IF.

Purpose of the Study:

  • To review the multifaceted benefits of intermittent fasting (IF).
  • To explore IF's impact on metabolism, endocrine and cardiovascular systems, cancer prevention, brain health, neurodegeneration, and aging.
  • To compare outcomes and mechanisms from rodent models and human studies.

Main Methods:

  • Review of experimental studies on rodent models.
  • Analysis of human investigations and clinical trials.
  • Comparative analysis of IF outcomes and underlying physiological mechanisms.

Main Results:

  • IF improves physiological function, enhances performance, and mitigates aging and disease processes.
  • Evidence from human and animal studies supports IF's role in slowing aging.
  • IF demonstrates benefits across metabolic, endocrine, cardiovascular, and neurological systems.

Conclusions:

  • Metabolic and cellular adaptations induced by IF contribute to disease prevention.
  • IF holds promise for maximizing healthspan and longevity with minimal adverse effects.
  • IF represents a viable non-pharmacological intervention for promoting healthy aging.