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THE RELATION OF THYROID DISTURBANCE AND ISCHEMIC HEART DISEASE IN IRAQI PATIENTS
1Department of Biochemistry, College of Medicine, Tikrit University, Iraq.
Insights
Thyroid hormones T3 and T4 were elevated in patients with ischemic heart disease (IHD). This study highlights potential thyroid dysfunction links to IHD, suggesting further research into mechanisms and clinical impacts.
Area of Science:
- Endocrinology
- Cardiology
- Metabolic Disorders
Background:
- Ischemic heart disease (IHD) is a significant global health concern.
- Thyroid dysfunction is increasingly recognized as a potential comorbidity affecting cardiovascular health.
- Understanding the interplay between thyroid function and IHD is crucial for comprehensive patient management.
Purpose of the Study:
- To investigate thyroid function parameters in patients with ischemic heart disease (IHD) in Baghdad.
- To compare thyroid hormone levels (T3, T4, TSH) and HbA1c between IHD patients and healthy controls.
- To explore correlations between thyroid dysfunction, hypertension, diabetes, and IHD.
Main Methods:
- A case-control study involving 60 Iraqi IHD patients and 30 healthy controls.
- Blood samples analyzed for thyroid hormones (T3, T4, TSH) and glycated hemoglobin (HbA1c) after fasting.
- Demographic data including age, sex, BMI, hypertension, and diabetes status were collected and analyzed.
Main Results:
- IHD patients exhibited significantly higher triiodothyronine (T3) and thyroxine (T4) levels compared to controls.
- No significant difference in thyroid-stimulating hormone (TSH) levels was observed between groups.
- Elevated HbA1c levels were noted in hypothyroid patients, and hyperthyroidism was more prevalent in hypertensive individuals, while hypothyroidism was more common in diabetics.
Conclusions:
- The study suggests potential alterations in thyroid hormone levels associated with ischemic heart disease.
- Findings indicate a possible link between thyroid dysfunction and the prevalence of hypertension and diabetes in IHD patients.
- Further research is warranted to elucidate the clinical implications and underlying mechanisms of thyroid dysfunction in IHD.
Abstract:
This study conducted in Baghdad focused on patients with coronary heart disease admitted to three hospitals. The study included 60 Iraqi patients with coronary heart disease and a control group of 30 healthy individuals. Blood samples were collected from both groups after fasting. The study analyzed the demographic characteristics of the patients and control group, including age groups, sex distribution, and BMI. The majority of patients had hypertension, while 58.33% had diabetes. The study found that IHD patients had significantly higher T3 and T4 levels compared to the control group. However, there was no significant difference in TSH levels. The study also examined thyroid function parameters among different age groups and found no significant differences in individuals with hypothyroidism. The highest prevalence of hyperthyroidism was among individuals with hypertension, while the highest spread of hypothyroidism was among individuals with diabetes. The study observed significant differences in mean HbA1c levels among the three groups, with the highest levels in patients with hypothyroidism. In conclusion, this study suggests potential alterations in thyroid function associated with ischemic heart disease and emphasizes the need for further research on the clinical implications and underlying mechanisms involved.
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