EVALUATION OF VITAMIN D SERUM LEVELS AND THYROID FUNCTION TEST IN HYPOTHYROIDISM IRAQI PATIENTS

The role of Vitamin D is primarily to maintain calcium and phosphate levels in the bloodstream. Significantly, steroid hormone receptors are the binding sites for both vitamin D and thyroid hormone. However, the vitamin D and thyroid function relationship is still not fully understood. The study aims to measure vitamin D serum levels and to investigate its relation with hypothyroidism in Iraq patients.This case-control study was carried out during the period from the first of March to the end of May 2023 in Baghdad City, Iraq. The study included 90 subjects that were divided into 2 groups. The first group consists of 60 people infected with hypothyroidism. The second group (control group) consists of 30 healthy people. Blood samples were assessed for serum vitamin D, TSH, T3 and T4 using a chemiluminescence microparticle immunoassay analyzer while serum anti-TPO used an enzyme-linked immunosorbent assay technique.The study showed that the level of T3, T4 and vitamin D in hypothyroidism patients significantly decreased compared to the control group (p<0.001). While TSH and anti-TPO levels in hypothyroidism patients significantly increase in comparison to the control group (p<0.001). The study found a significant negative correlation between (vitamin D and T3) with (p<0.01), while the study showed a significant positive correlation between (TSH and vitamin D) with (p<0.01). Finally, the study demonstrated a non-significant weak negative correlation (p>0.05) between (vitamin D and T4), but a non-significant weak positive correlation (p>0.05) between (vitamin D and anti-TPO).Patients with hypothyroidism had noticeably low levels of vitamin D, indicating that this vitamin D may be involved in the aetiology of hypothyroidism.