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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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ASSOCIATION OF PLASMA NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN WITH METABOLIC SYNDROME.

E Mahmood1, N Hilal1, M Abdul-Aziz1

  • 1College of Medicine, Tikrit University, Iraq.

Georgian Medical News
|July 4, 2024
PubMed
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Elevated Neutrophil gelatinase-associated lipocalin (NGAL) levels are significantly linked to metabolic syndrome, hypertension, and diabetes. This finding highlights NGAL as a key risk factor for cardiovascular disease, emphasizing the need for metabolic syndrome management.

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Area of Science:

  • Clinical Biochemistry
  • Cardiovascular Research
  • Metabolic Disorders

Background:

  • Metabolic syndrome (MetS) is a cluster of conditions increasing cardiovascular disease (CVD) risk.
  • Hypertension and diabetes mellitus (DM) are major components and risk factors associated with MetS.
  • Neutrophil gelatinase-associated lipocalin (NGAL) is an emerging biomarker with potential roles in inflammation and cardiovascular health.

Purpose of the Study:

  • To investigate the association between serum Neutrophil gelatinase-associated lipocalin (NGAL) levels and Metabolic Syndrome (MetS).
  • To compare NGAL levels, hemoglobin A1c (HbA1c), and lipid profiles in MetS patients versus a control group.
  • To assess the role of NGAL as a potential risk factor for cardiovascular events in the context of MetS.

Main Methods:

  • A prospective hospital-based study involving 60 MetS patients and 30 healthy controls (aged 18-50).
  • Standard diagnostic criteria for MetS were applied, including waist circumference, BMI, and waist-to-hip ratio.
  • Serum NGAL, HbA1c, and lipid profiles were measured and compared between groups.

Main Results:

  • Patients with MetS exhibited significantly higher serum NGAL levels compared to the control group (p<0.001).
  • MetS patients showed significantly different HbA1c and lipid profile concentrations (p<0.001) compared to controls.
  • A high level of NGAL was associated with MetS, indicating a significant risk factor for cardiovascular disease incidence and mortality.

Conclusions:

  • Elevated serum NGAL is significantly associated with Metabolic Syndrome.
  • NGAL may serve as a crucial biomarker for cardiovascular disease risk in individuals with MetS.
  • Effective management and prevention of MetS risk factors are vital for reducing cardiovascular disease prevalence.