EVALUATION OF SERUM VASPIN LEVEL IN IRAQI WOMEN WITH GESTATIONAL DIABETES MELLITUS

Area of Science:

• Endocrinology
• Metabolic Disorders
• Pregnancy Complications

Background:

• Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance during pregnancy.
• Understanding biomarkers associated with GDM is crucial for effective management.
• Vaspin is a protein that has been implicated in metabolic regulation.

Purpose of the Study:

• To quantify serum vaspin levels in pregnant women with GDM.
• To investigate the association between vaspin and key metabolic parameters including insulin resistance, HbA1c, and lipid profiles in GDM.

Main Methods:

• A case-control study involving 90 pregnant women (60 with GDM, 30 controls).
• Serum samples were analyzed for vaspin, insulin, HbA1c, fasting blood glucose, and lipid profiles (HDL, LDL, TG, TC).
• Measurements were performed using ELISA and colorimetric methods.

Main Results:

• Significantly higher serum vaspin levels were observed in the GDM group compared to controls (268.98±154.02 ng/ml).
• Insulin, HbA1c, and fasting blood glucose were also significantly elevated in women with GDM.
• No significant differences were found in insulin resistance, HDL, LDL, triglyceride, or total cholesterol levels between the groups.

Conclusions:

• Vaspin is elevated in gestational diabetes mellitus.
• The increased vaspin levels in GDM do not show a negative correlation with HbA1c, insulin resistance, or the measured lipid profile parameters.