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LEVELS OF OSTEOPROTEGERIN AND IRISIN IN POSTMENOPAUSAL OSTEOPOROSIS WOMEN
Georgian Medical News
|September 4, 2024
Summary
Osteoprotegerin levels were higher in postmenopausal osteoporosis patients, while irisin levels were lower. A positive correlation was found between osteoprotegerin and irisin in these women.
Area of Science:
- Endocrinology
- Bone Metabolism
- Gerontology
Background:
- Osteoporosis (OP) is a prevalent skeletal disorder characterized by low bone mass and increased fracture risk.
- Osteoprotegerin is crucial in regulating bone resorption, while irisin, a muscle-secreted hormone, influences various metabolic processes including bone metabolism.
Purpose of the Study:
- To investigate the serum levels of osteoprotegerin and irisin in postmenopausal women with osteoporosis.
- To explore the relationship between these markers and osteoporosis in the studied population.
Main Methods:
- A prospective cross-sectional study was conducted on 90 Iraqi postmenopausal women (60 with osteoporosis, 30 controls).
- Serum osteoprotegerin and irisin levels were measured using ELISA kits.
- Bone mineral density was assessed using DEXA.
Main Results:
- Mean serum osteoprotegerin levels were significantly higher in postmenopausal osteoporosis women compared to controls (P=0.0007).
- Mean serum irisin levels were significantly lower in postmenopausal osteoporosis women compared to controls (P=0.0004).
Conclusions:
- The study indicates altered levels of osteoprotegerin and irisin in postmenopausal osteoporosis.
- A positive correlation (R=0.175) was observed between serum osteoprotegerin and irisin levels in postmenopausal women with osteoporosis.
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