EVALUATION OF VITAMIN D SERUM LEVELS AND THYROID FUNCTION TEST IN HYPOTHYROIDISM IRAQI PATIENTS

Area of Science:

• Endocrinology
• Nutritional Science
• Clinical Medicine

Background:

• Vitamin D is crucial for calcium and phosphate homeostasis.
• Steroid hormone receptors bind both vitamin D and thyroid hormone, hinting at a potential link.
• The precise relationship between vitamin D and thyroid function remains incompletely understood.

Purpose of the Study:

• To assess serum vitamin D levels in Iraqi patients.
• To investigate the association between vitamin D and hypothyroidism in this population.

Main Methods:

• A case-control study conducted in Baghdad, Iraq, from March to May 2023.
• Included 90 participants: 60 with hypothyroidism and 30 healthy controls.
• Measured serum vitamin D, TSH, T3, T4 via chemiluminescence immunoassay and anti-TPO via ELISA.

Main Results:

• Hypothyroid patients exhibited significantly lower serum levels of T3, T4, and vitamin D compared to controls (p<0.001).
• TSH and anti-TPO levels were significantly higher in hypothyroid patients (p<0.001).
• Significant negative correlation found between vitamin D and T3 (p<0.01), and positive correlation between vitamin D and TSH (p<0.01).

Conclusions:

• Patients with hypothyroidism demonstrated markedly reduced vitamin D levels.
• These findings suggest vitamin D may play a role in the etiology of hypothyroidism.
• Further research is needed to elucidate the complex interplay between vitamin D and thyroid function.