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SALIVARY AND SERUM PROTEIN Z, AND Β-ARRESTIN-1 AS A NOVEL DIAGNOSTIC MARKER OF PATIENTS WITH DIABETES MELLITUS TYPE 2
Z Rmaidh1, Y Tawfeeq2, S Khalaf2
11Department of Oral Pathology, College of Dentistry, Tikrit University, Iraq.
Aim:
To investigate serum and salivary protein Z and β-arrestin-1 levels as predictors of T2DM as compared to the healthy controls.
Methods:
The assay comprised 98 subjects, enrolled of both genders in the age range of 30-58 years old. Volunteers were categorized into two groups: 49 healthy individuals and 49 DM patients. The blood and salivary samples were collected and sent for biochemical analysis to measure the protein Z and β-arrestin-1 levels.
Results:
The DM group exhibited higher salivary and serum β-arrestin-1 compared to the control group. The findings revealed noticeably elevated serum and salivary protein levels. Z, HbA1c and glucose levels in the DM group. Protein Z showed significant negative correlations with HbA1c, supporting the observation of decreased protein Z in poorer glycemic control. Further analysis showed that serum and salivary protein Z are (87.8 and 46.9)% sensitive and (89.8 and 100.0)% specific with a cut-off value (≤1.500, and ≤141.6), respectively. The ROC Curve cut-off value of serum and salivary alpha β-arrestin-1observed was (≥14.80, and ≥2.290 pg/ml), respectively. The sensitivity was (95.9, 63.3)% and the specificity was (91.8 and 93.9)%, respectively.
Conclusion:
Our findings demonstrated that higher salivary levels of β-arrestin-1 and lower levels of protein Z were associated with diabetes mellitus and could serve as an adjuvant diagnostic tool for diabetes.
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