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THE ROLE OF MYONECTIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.

R Tuama1, E Sarhat2

  • 11College of Science, Tikrit University, Iraq.

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This study found lower myonectin levels in type 2 diabetes patients, correlating with metabolic markers. Myonectin may help predict diabetes development.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases

Background:

  • Diabetes mellitus is a chronic condition causing significant tissue damage.
  • Type 2 diabetes mellitus (T2DM) is a prevalent form of diabetes.
  • Understanding biomarkers for T2DM is crucial for early detection and management.

Purpose of the Study:

  • To investigate the association between myonectin levels and glycemic control in T2DM patients.
  • To explore the potential of myonectin as a predictive marker for T2DM.

Main Methods:

  • A prospective study involving 60 T2DM patients and 30 healthy controls.
  • Serum myonectin levels and glycemic control parameters (FBS, HbA1C) were measured.
  • Quantification was performed using a Cobas C 111 analyzer.

Main Results:

  • T2DM patients exhibited significantly higher fasting blood sugar (FBS) and HbA1C levels compared to controls (p≤0.0001).
  • Serum myonectin levels were significantly reduced in T2DM patients (292.78±110.32 pg/ml) compared to controls (379.72±140.64 pg/ml) (p>0.005).
  • A significant correlation was observed between serum myonectin levels and metabolic markers of T2DM.

Conclusions:

  • Circulating myonectin levels are decreased in individuals with T2DM.
  • Myonectin levels are associated with key metabolic indicators of T2DM.
  • Myonectin shows potential as a predictive biomarker for T2DM development.