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ASSOCIATION OF ADIPOKINES AND VITAMIN D IN CHILDREN WITH AUTISM SPECTRUM DISORDER
Insights
Children with autism spectrum disorder (ASD) show lower vitamin D and irisin levels, alongside higher leptin and visfatin. These biomarker differences may influence ASD onset and severity.
Area of Science:
- Biochemistry
- Pediatrics
- Neuroscience
Background:
- Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
- Biomarkers in serum may offer insights into ASD pathophysiology.
- Investigating vitamin D, leptin, irisin, and visfatin in children with ASD.
Purpose of the Study:
- To compare serum concentrations of vitamin D, leptin, irisin, and visfatin in children with ASD versus healthy controls.
- To identify potential biochemical markers associated with ASD.
Main Methods:
- Serum samples were collected from 50 children diagnosed with ASD and 30 healthy children.
- Quantification of serum vitamin D, leptin, irisin, and visfatin using appropriate assays.
Main Results:
- Children with ASD exhibited significantly lower serum levels of vitamin D and irisin compared to controls (p<0.0001 and p<0.05).
- Serum concentrations of leptin and visfatin were significantly elevated in the ASD group compared to the control group.
Conclusions:
- Lower serum vitamin D and irisin levels are associated with ASD in children.
- Elevated serum leptin and visfatin levels are also observed in children with ASD.
- These altered biomarker levels may play a role in the development and severity of autism spectrum disorder.
Background:
This study tested the serum concentration of vitamin D, leptin as a biomolecule in serum of children with autism spectrum disorder (ASD).
Methods:
Blood samples were obtained from (50) patients with autism, compared with healthy group as a control (30). Leptin, irisin and visfatin was detected.
Results:
The amounts of leptin and visfatin were much higher in autistic group than healthy control group. Also, there was a significant reduction in vitamin D and irisin in the serum vitamin D, and irisin in autistic patients in comparison with control groups (p<0.0001 and p<0.05).
Conclusion:
Children presented with ASD presented with lower levels of serum vitamin D, and irisin. Also, another common factor in the diagnosis in autistic children, were higher levels of visfatin, and leptin possibly contributing to the onset and severity of ASD.
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