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ASSOCIATION OF ADIPOKINES AND VITAMIN D IN CHILDREN WITH AUTISM SPECTRUM DISORDER
Georgian Medical News
|December 10, 2025
Summary
Children with autism spectrum disorder (ASD) show lower vitamin D and irisin levels, alongside higher leptin and visfatin. These biomarker differences may influence ASD onset and severity.
Area of Science:
- Biochemistry
- Pediatrics
- Neuroscience
Background:
- Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
- Biomarkers in serum may offer insights into ASD pathophysiology.
- Investigating vitamin D, leptin, irisin, and visfatin in children with ASD.
Purpose of the Study:
- To compare serum concentrations of vitamin D, leptin, irisin, and visfatin in children with ASD versus healthy controls.
- To identify potential biochemical markers associated with ASD.
Main Methods:
- Serum samples were collected from 50 children diagnosed with ASD and 30 healthy children.
- Quantification of serum vitamin D, leptin, irisin, and visfatin using appropriate assays.
Main Results:
- Children with ASD exhibited significantly lower serum levels of vitamin D and irisin compared to controls (p<0.0001 and p<0.05).
- Serum concentrations of leptin and visfatin were significantly elevated in the ASD group compared to the control group.
Conclusions:
- Lower serum vitamin D and irisin levels are associated with ASD in children.
- Elevated serum leptin and visfatin levels are also observed in children with ASD.
- These altered biomarker levels may play a role in the development and severity of autism spectrum disorder.
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