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PARADOXICAL ELEVATION OF PLATELET INDICES IN SUDANESE PATIENTS WITH CHRONIC HEPATITIS B: A CROSS-SECTIONAL ANALYSIS.

N Mohamed¹, R Yousef², A Elgak²

¹1A'Sharqiyah University, Ibra, Oman.

Georgian Medical News

|November 28, 2025

Summary

This summary is machine-generated.

In Sudan, chronic hepatitis B patients paradoxically show higher platelet counts and related indices. These platelet markers had limited use in determining disease activity in this population.

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Area of Science:

Hepatology
Hematology
Virology

Background:

Chronic hepatitis B virus (HBV) infection is a significant health concern in Sudan.
Platelet indices are explored as potential non-invasive markers for liver disease severity.
Limited data exists on platelet indices in Sudanese chronic hepatitis B patients.

Purpose of the Study:

To evaluate platelet indices in Sudanese patients with chronic hepatitis B.
To assess the relationship between platelet indices and HBV disease phases, age, and gender.

Main Methods:

A case-control study involving 198 participants (127 chronic HBV patients, 71 healthy controls) from Khartoum State, Sudan.
Automated hematology analyzers were used to measure platelet indices.
HBV DNA quantification was performed using real-time PCR, and patients were stratified into disease phases based on viral load.

Main Results:

Chronic HBV patients exhibited significantly elevated platelet counts, mean platelet volume, platelet distribution width, and plateletcrit compared to controls.
No significant differences in platelet indices were observed across different HBV disease phases.
Platelet indices did not show significant variations between demographic groups (age and gender).

Conclusions:

Sudanese chronic HBV patients present with elevated platelet indices, contrary to typical associations with thrombocytopenia.
Platelet parameters demonstrated limited correlation with disease phases, indicating reduced utility as markers of HBV activity in this population.