Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

1.6K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
1.6K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

98
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
98
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

429
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
429
Aging01:26

Aging

51
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
51
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

475
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
475
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FAK inhibition following acute olfactory epithelial inflammation promotes neurogenesis and functional recovery through stem cell CNTF.

Stem cells (Dayton, Ohio)·2026
Same author

Metabolome contribution to sex differences in the link between alcohol consumption and type 2 diabetes: a prospective analysis in the Hispanic Community Health Study/Study of Latinos.

The American journal of clinical nutrition·2026
Same author

Development of a novel microsampling device to standardize the analysis of intranasal inflammatory biomarkers.

Methods (San Diego, Calif.)·2025
Same author

Non-Invasive Wearable Technology to Predict Heart Failure Decompensation.

Journal of clinical medicine·2025
Same author

Evaluating early cardiology involvement and survival outcomes across NT-proBNP levels: An island-wide retrospective cohort study.

European journal of heart failure·2025
Same author

Interplays of <i>ADH1B</i> Genotype, Alcohol Consumption, and Gut Microbiota in Relation to Insulin Resistance.

Nutrients·2025

Related Experiment Video

Updated: Jun 30, 2025

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

4.0K

Cerebellum and Aging: Update and Challenges.

Christopher L McElroy, Brian Wang, Hongxia Zhang

    Aging and Disease
    |March 19, 2024
    PubMed
    Summary
    This summary is machine-generated.

    The aging cerebellum impacts balance, motor skills, and cognitive function. Understanding its accelerated aging is key to addressing neurodegenerative diseases and developing interventions.

    More Related Videos

    Cerebellar Regional Dissection for Molecular Analysis
    08:51

    Cerebellar Regional Dissection for Molecular Analysis

    Published on: December 5, 2020

    4.8K
    Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
    12:28

    Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

    Published on: June 3, 2020

    17.4K

    Related Experiment Videos

    Last Updated: Jun 30, 2025

    A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
    11:50

    A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

    Published on: February 4, 2022

    4.0K
    Cerebellar Regional Dissection for Molecular Analysis
    08:51

    Cerebellar Regional Dissection for Molecular Analysis

    Published on: December 5, 2020

    4.8K
    Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
    12:28

    Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

    Published on: June 3, 2020

    17.4K

    Area of Science:

    • Neuroscience
    • Gerontology

    Background:

    • The cerebellum is crucial for motor control, balance, and increasingly recognized for cognitive functions.
    • Cerebellar aging is associated with declines in motor skills and increased fall risk.
    • The cerebellum ages faster than other brain regions like the hippocampus.

    Purpose of the Study:

    • To summarize cerebellar functions, particularly in aging.
    • To investigate the accelerated aging of the cerebellum at cellular, molecular, and functional levels.
    • To explore the cerebellum's role in neurodegenerative diseases and the impact of alcoholism.

    Main Methods:

    • Literature review and synthesis of existing research on cerebellar aging.
    • Analysis of cellular and molecular changes associated with cerebellar aging.
    • Examination of functional consequences of cerebellar aging.

    Main Results:

    • Cerebellar aging affects motor function, balance, and cognition.
    • The cerebellum exhibits accelerated aging compared to other brain areas.
    • The cerebellum is implicated in Alzheimer's, Parkinson's, and Multiple Sclerosis.

    Conclusions:

    • The cerebellum's accelerated aging necessitates further research into its multifaceted roles.
    • Understanding cerebellar aging mechanisms can inform strategies against neurodegeneration.
    • Interventions targeting cerebellar health may mitigate age-related decline and disease progression.