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Extracellular Matrix

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...

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Related Experiment Video

Updated: Jul 15, 2026

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Paintable Decellularized-ECM Hydrogel for Preventing Cardiac Tissue Damage.

Jaewoo Lee¹, Seul-Gi Lee², Beom-Seok Kim^3,4

¹School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 151-742, Republic of Korea.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|March 19, 2024

Summary

A new paintable hydrogel delivers heart decellularized extracellular matrix (hdECM) for myocardial infarction (MI) therapy. This novel approach promotes cardiac regeneration and improves heart function post-MI.

Keywords:

Painting heart‐decellularized extracellular matrix hydrogel myocardial infarction vascularization

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Area of Science:

Biomaterials Science
Regenerative Medicine
Cardiovascular Research

Background:

Heart decellularized extracellular matrix (hdECM) shows therapeutic potential for myocardial infarction (MI).
Current hdECM delivery methods (injection, patch) have limitations.
Novel delivery systems are needed for effective MI treatment.

Purpose of the Study:

To develop and evaluate a novel, paintable hydrogel for hdECM delivery in MI therapy.
To assess the efficacy of the hdECM-loaded hydrogel (pdHA_t) in a rat MI model.
To investigate the potential of pdHA_t for cardiac tissue regeneration and functional recovery.

Main Methods:

Fabrication of a paintable hydrogel loaded with hdECM (pdHA_t).
Assessment of hydrogel properties: adhesion, swelling, and washability.
In vivo evaluation of pdHA_t in a rat MI model over 28 days.

Main Results:

The pdHA_t demonstrated robust epicardial adhesion with minimal swelling.
The hydrogel was easily removable, preventing adhesion to surrounding tissues.
In vivo studies showed reduced ventricular wall thinning and promoted neo-vascularization in the MI region.

Conclusions:

The pdHA_t is a promising, scalable strategy for MI treatment and cardiac regeneration.
This novel delivery system enhances cardiac function and tissue repair post-MI.
The paintable hydrogel offers improved therapeutic outcomes for myocardial infarction patients.