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Drug fever: a narrative review
Hidehiro Someko1,2, Yuki Kataoka2,3,4,5, Taku Obara6,7
1Department of General Internal Medicine, Asahi General Hospital.
Annals of Clinical Epidemiology
|March 20, 2024
Summary
Drug fever, an adverse drug reaction causing fever, lacks a clear definition, leading to inconsistent reporting. This review synthesizes existing knowledge and explores using pharmacovigilance databases for future research.
Area of Science:
- Pharmacology
- Clinical Medicine
- Drug Safety
Background:
- Drug fever is a common adverse drug reaction characterized by fever.
- A lack of consensus on its definition leads to inconsistent literature descriptions.
- Updated knowledge on drug fever is crucial for clinicians.
Purpose of the Study:
- To provide a comprehensive summary of drug fever features.
- To explore the utility of pharmacovigilance databases in drug fever research.
Main Methods:
- Narrative review of earliest literature on drug fever.
- Discussion of modern research methods utilizing pharmacovigilance databases.
Main Results:
- Summarized key aspects of drug fever: definition, epidemiology, risk factors, clinical presentation, diagnosis, treatment, and prognosis.
- Outlined potential applications of pharmacovigilance databases and new research methodologies for studying drug fever.
Conclusions:
- A unified definition of drug fever is needed.
- Pharmacovigilance databases offer promising avenues for advancing drug fever research.
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