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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Fabrication of Orally Fast-Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze-Drying Method.

Chaowalit Monton1,2,3, Poj Kulvanich4, Natawat Chankana2,5

  • 1Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani, Thailand.

Medical Cannabis and Cannabinoids
|March 20, 2024
PubMed
Summary
This summary is machine-generated.

Novel fast-disintegrating wafer tablets were developed for cannabis extract delivery. These orally disintegrating tablets offer improved patient convenience and enhanced drug delivery through a freeze-drying technique.

Keywords:
CannabinoidsCannabisGelatinMannitolMarijuana

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Cannabis Therapeutics

Background:

  • Development of novel dosage forms for cannabis extract is crucial for improving drug delivery and patient convenience.
  • Existing cannabis formulations may present challenges in terms of bioavailability and ease of administration.

Purpose of the Study:

  • To develop and characterize orally fast-disintegrating wafer tablets containing cannabis extract.
  • To optimize a formulation for enhanced cannabis extract delivery and patient compliance.

Main Methods:

  • Freeze-drying technique was employed to fabricate wafer tablets.
  • Formulation included cannabis extract, Tween® 80, gelatin, mannitol, sucralose, and parabens.
  • Characterization involved assessing physical properties, disintegration time, and cannabinoid content.

Main Results:

  • Optimized formulation contained 5% cannabis extract, 1.25% Tween® 80, 5% gelatin, 88.34% mannitol, 0.2% sucralose, and preservatives.
  • Wafer tablets exhibited a porous structure, ~200 mg weight, <1.4% weight variation, pH 5.12, and disintegrated within 10 seconds.
  • Tablets contained ~2.8 mg Delta-9-THC and ~0.9 mg CBD, dissolved rapidly in simulated saliva.

Conclusions:

  • Successfully fabricated orally fast-disintegrating wafer tablets containing cannabis extract.
  • The developed wafer tablets possess desirable characteristics for improved cannabis drug delivery.
  • This novel dosage form enhances patient convenience and potentially bioavailability.