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Fingerroot Extract Oral Spray for Anticariogenic Purpose: Integration of Ultrasound-Assisted Extraction and Solvent
Chaowalit Monton1,2,3, Thaniya Wunnakup1, Jirapornchai Suksaeree4
1Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani, 12000, Thailand, rsu.ac.th.
Advances in Pharmacological and Pharmaceutical Sciences
|June 29, 2026
Summary
Fingerroot extract shows promise for oral health. Optimized extraction and solvent systems were used to create an oral spray with anticariogenic activity against Streptococcus mutans.
Area of Science:
- Pharmacognosy and Natural Products Chemistry
- Oral Health and Microbiology
- Formulation Science
Background:
- Fingerroot (Boesenbergia rotunda) possesses known anticariogenic properties.
- Streptococcus mutans is a primary pathogen in dental caries.
- Development of effective oral delivery systems for natural compounds is crucial.
Purpose of the Study:
- To optimize ultrasound-assisted extraction (UAE) of fingerroot for key bioactive compounds.
- To select optimal solvent systems for flavonoid recovery and solubilization in an oral spray.
- To develop and evaluate an anticariogenic oral spray formulation from fingerroot extract.
Main Methods:
- Box-Behnken design for UAE condition optimization (time, solvent ratio, ethanol concentration).
- I-optimal design for solvent system selection (water, PEG 400, ethanol).
- Formulation of oral sprays with optimized extract and excipients; stability and antimicrobial testing.
Main Results:
- Optimal UAE conditions (45 min, 30:1 ratio, 85% ethanol) maximized pinocembrin, pinostrobin, and panduratin A.
- Selected solvent systems effectively recovered and solubilized flavonoids for spray formulation.
- Developed oral sprays exhibited anticariogenic activity against S. mutans; stability showed pH/flavonoid decline but stable viscosity/antimicrobial action.
Conclusions:
- UAE and solvent system optimization successfully yielded a fingerroot oral spray formulation.
- The developed fingerroot oral spray demonstrates potential as an anticariogenic agent.
- Further research is warranted to assess long-term stability and clinical efficacy.
