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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Correction: Aleemardani et al. Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury. <i>Biomedicines</i> 2022, <i>10</i>, 73.

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Nanocarrier-based gene delivery for immune cell engineering.

Alireza Gharatape1, Hamid Sadeghi-Abandansari2, Alexander Seifalian3

  • 1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. refaridi@sina.tums.ac.ir.

Journal of Materials Chemistry. B
|March 20, 2024
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Summary

Nanocarriers offer a promising non-viral alternative for genetically modifying immune cells, advancing cancer immunotherapy. This review explores nanoparticle-based gene delivery strategies for improved efficiency and safety in preclinical cancer treatment.

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Area of Science:

  • Biotechnology and Nanomedicine
  • Cancer Immunotherapy
  • Gene Delivery Systems

Background:

  • Chimeric antigen receptor T cell therapies represent a significant advance in cancer treatment.
  • Current immune cell therapies predominantly rely on viral methods for genetic modification.
  • Non-viral gene delivery methods, particularly nanocarrier-based approaches, are under development.

Purpose of the Study:

  • To review current advancements in nanoparticle-based gene delivery for immune cells.
  • To identify strategies for overcoming challenges in nanocarrier-mediated gene delivery.
  • To assess the impact of nanocarriers on the efficiency, safety, and specificity of gene delivery for cancer immunotherapy.

Main Methods:

  • Focus on polymeric and lipid-based nanocarriers.
  • Review of recent preclinical applications in cancer immunotherapy.
  • Analysis of strategies to enhance gene delivery efficiency and safety.

Main Results:

  • Nanocarriers possess versatile physicochemical properties suitable for immune cell gene delivery.
  • In vivo nanocarrier-based gene delivery could replace expensive autologous cell manufacturing.
  • Polymeric and lipid-based nanocarriers show potential in preclinical cancer immunotherapy models.

Conclusions:

  • Nanocarrier-based gene delivery is a developing field with the potential to revolutionize cancer immunotherapy.
  • Addressing challenges in nanocarrier design and application is crucial for clinical translation.
  • Further research into nanoparticle-mediated gene delivery promises safer and more effective off-the-shelf immunotherapies.