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Updated: Jun 30, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Rhodium-Catalyzed Enantioselective Cyclization of 2-Allenylbenzoxazoles
Antonia Becker1, Felix Bauer1, Bernhard Breit1
1Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104 Freiburg, Germany.
Abstract:
The enantioselective rhodium-catalyzed cyclization of 2-allenylbenzoxazoles to the corresponding vinyl-functionalized, fused heterocyclic structures is reported. The presented method offers several advantages, including the use of low catalyst loadings, commercially available catalyst precursors, and mild reaction conditions. Due to its broad scope, scalability, and valuable products, we consider this methodology to be a useful tool for the construction of benzoxazole-containing building blocks.
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