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Related Experiment Video

Updated: Jun 30, 2025

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
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Mortality Factors in Crush Syndrome.

Engin Onan1, Dilek Torun1, Rüya Kozanoğlu1

  • 1Department of Nephrology, Baskent University Adana Dr. Turgut Noyan Traning and Research Hospital, Adana-Türkiye.

Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : TJTES
|March 20, 2024
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Summary

Low systolic blood pressure in Crush Syndrome patients after earthquakes is a significant predictor of mortality. Prompt blood pressure monitoring and aggressive fluid therapy are crucial for improving outcomes in these critically ill patients.

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Area of Science:

  • Emergency Medicine
  • Trauma Surgery
  • Nephrology

Background:

  • Crush Syndrome is a severe complication of earthquakes, leading to significant morbidity and mortality.
  • Current knowledge is limited due to a lack of randomized controlled trials, relying heavily on expert experience.
  • The 2023 Pazarcik and Elbistan earthquakes provide a critical dataset for studying Crush Syndrome.

Purpose of the Study:

  • To analyze the epidemiological and demographic characteristics of earthquake victims with Crush Syndrome.
  • To investigate clinical outcomes, including acute kidney injury (AKI) and mortality rates.
  • To identify key factors influencing mortality in Crush Syndrome patients.

Main Methods:

  • A cross-sectional, observational, retrospective study of 610 earthquake victims.
  • Inclusion of 128 patients diagnosed with Crush Syndrome.
  • Analysis of hospital records and national registries, with regression analysis for mortality factors.

Main Results:

  • The study included 128 Crush Syndrome patients (100 adults, 28 children), with 64 females.
  • Acute kidney injury (AKI) occurred in 32.8% of patients, with 69% requiring hemodialysis.
  • Low systolic blood pressure on admission was the sole significant predictor of mortality (HR: 1.088, p=0.021).

Conclusions:

  • Low systolic blood pressure is a critical risk factor for mortality in earthquake-related Crush Syndrome.
  • Emphasizes the need for vigilant blood pressure monitoring, even under rubble.
  • Suggests aggressive fluid therapy for patients presenting with hypotension.