Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

606
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
606
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

985
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
985

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Female ILCs on the spotlight.

Nature immunology·2025
Same author

Human CD127 negative ILC2s show immunological memory.

The Journal of experimental medicine·2024
Same author

Laboratory mice with a wild microbiota generate strong allergic immune responses.

Science immunology·2023
Same author

Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases.

Science immunology·2021
Same author

Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.

PloS one·2019
Same author

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

The Journal of experimental medicine·2016

Related Experiment Video

Updated: Jun 30, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

1.9K

New insights into ILC2 memory.

Itziar Martinez-Gonzalez1, Fumio Takei2

  • 1Molecular, Tumor and Cell biology, Karolinska Institute, Stockholm, Sweden.

Immunological Reviews
|March 20, 2024
PubMed
Summary

Group 2 innate lymphoid cells (ILC2s) develop immune memory, enhancing responses to allergens. This review explores the mechanisms and implications of memory ILC2s in allergic diseases.

Keywords:
ILC2sallergyimmune memorytype 2 inflammation

More Related Videos

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

5.6K
Imaging the Human Immunological Synapse
09:37

Imaging the Human Immunological Synapse

Published on: December 26, 2019

14.2K

Related Experiment Videos

Last Updated: Jun 30, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

1.9K
Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

5.6K
Imaging the Human Immunological Synapse
09:37

Imaging the Human Immunological Synapse

Published on: December 26, 2019

14.2K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Group 2 innate lymphoid cells (ILC2s) are key players in type 2 immunity.
  • They reside at barrier tissues and respond to alarmins by releasing IL-5 and IL-13.

Purpose of the Study:

  • To review recent findings on immune memory mechanisms in ILC2s.
  • To discuss the role of memory ILC2s in allergic diseases.

Main Methods:

  • Review of current literature on ILC2 memory.
  • Analysis of cellular and molecular mechanisms in mice and humans.

Main Results:

  • Some activated ILC2s gain immunological memory.
  • Memory ILC2s provide enhanced responses upon re-exposure to allergens.

Conclusions:

  • Understanding ILC2 memory mechanisms is crucial.
  • Memory ILC2s have significant implications for allergic disease pathogenesis and treatment.