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Updated: Jun 30, 2025

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

Published on: October 25, 2021

Advancements in Nanoparticle Characterization.

Rachael M Crist¹, Jeffrey D Clogston², Stephan T Stern³

¹Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. rachael.crist@nih.gov.

Methods in Molecular Biology (Clifton, N.J.)

|March 20, 2024

Summary

This summary is machine-generated.

Nanotechnology enables advanced drug delivery systems, including cancer therapies and mRNA vaccines. This work details methods for characterizing nanoparticles and assessing their safety and efficacy in drug delivery applications.

Keywords:

Cancer Immunotoxicity Nanomedicine Oncology Pharmacology Physicochemical characterization

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Last Updated: Jun 30, 2025

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

Published on: October 25, 2021

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

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Published on: October 20, 2020

High Resolution Physical Characterization of Single Metallic Nanoparticles

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

Area of Science:

Biomedical Engineering
Materials Science
Pharmacology

Background:

Nanotechnology has revolutionized drug delivery over the past 20 years.
Key innovations include cancer therapies, imaging agents, vaccine strategies, and mRNA lipid nanoparticles for SARS-CoV-2.
Technological advancements are crucial for understanding novel nanotherapies.

Purpose of the Study:

To provide updated protocols and methods for nanoparticle characterization.
To detail in vitro and in vivo assays for assessing nanoparticle immunotoxicity.
To describe pharmacological assays for evaluating drug release and tissue distribution.

Main Methods:

Physicochemical characterization of nanoparticles using established and novel techniques.
In vitro and in vivo immunotoxicity testing.
Pharmacological assays for drug release kinetics and biodistribution studies.

Main Results:

Comprehensive overview of nanoparticle characterization methodologies.
Detailed protocols for assessing potential immunotoxicities.
Methods for evaluating the pharmacological performance of nanodrugs.

Conclusions:

This resource offers essential methods for advancing nanomedicine research.
Characterization and safety assessments are critical for the clinical translation of nanodrugs.
Updated methodologies support the development of effective and safe nanotechnology-based therapeutics.