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Updated: Jun 30, 2025

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Piston-driven automated liquid handlers.

Joachim Schuster¹, Vinay Kamuju¹, Jin Zhou¹

¹Lonza Pharma and Biotech, Drug Product Services, Basel, Switzerland.

SLAS Technology

|March 20, 2024

Summary

This summary is machine-generated.

Automated liquid handlers (ALHs) address laboratory bottlenecks caused by manual sample preparation. These systems enhance efficiency, data quality, and cost-effectiveness, transforming laboratory workflows.

Keywords:

Automated liquid handler Automation Data quality Dispensing Futuristic Pipetting Robotics Sustainability

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Area of Science:

Laboratory automation
Analytical chemistry
Biotechnology

Background:

Manual sample preparation is a significant bottleneck in laboratory capacity, often exceeding instrument analysis time.
Repetitive tasks like low-microliter pipetting are labor-intensive, prone to errors, and can increase analytical variability.
Modern laboratories face challenges in scaling throughput while maintaining accuracy with manual workflows.

Purpose of the Study:

To review considerations for implementing automated liquid handlers (ALHs) in the microliter range.
To highlight the advantages and challenges of transitioning from manual to automated sample preparation.
To focus on the impact of sensor-controlled pipetting in ALHs.

Main Methods:

Review of existing literature and case studies on automated liquid handling.
Analysis of differences in liquid handling techniques between manual and automated methods.
Evaluation of benefits including efficiency, data quality, cost-effectiveness, safety, and sustainability.

Main Results:

ALHs significantly improve laboratory efficiency, throughput, and cost-effectiveness.
Sensor-controlled pipetting in ALHs enhances accuracy and reduces experimental variability.
Automation leads to improved data quality, safety, documentation, and sustainability.

Conclusions:

Automated liquid handlers offer substantial advantages for modern laboratories, despite implementation challenges.
Transitioning to ALHs can transform laboratory operations by increasing capacity and reliability.
The benefits of ALHs include enhanced efficiency, superior data quality, and improved laboratory safety and sustainability.