Immune patterns of cuproptosis in ischemic heart failure: A transcriptome analysis

Area of Science:

• Cell Biology
• Cardiovascular Disease
• Immunology

Background:

• Cuproptosis is a programmed cell death pathway affecting the tricarboxylic acid (TCA) cycle.
• Its role in ischemic heart failure (IHF) progression remains unexplored.

Purpose of the Study:

• Investigate cuproptosis-related gene expression in IHF.
• Develop a risk prediction model for IHF using cuproptosis genes.
• Evaluate the association between cuproptosis and the IHF immune microenvironment.

Main Methods:

• Analyzed expression of 10 cuproptosis-related genes in healthy and IHF samples.
• Developed a risk prediction model based on differential gene expression.
• Assessed immune cell infiltration, immune gene sets, and HLA genes in relation to cuproptosis.

Main Results:

• Identified differential expression of cuproptosis genes in IHF.
• Developed a predictive model distinguishing healthy and IHF samples.
• Found significant associations between cuproptosis and the IHF immune microenvironment, including distinct expression patterns and immune characteristics.

Conclusions:

• Cuproptosis significantly influences the immune microenvironment in ischemic heart failure.
• Provides insights for future research on cuproptosis mechanisms in IHF.
• Highlights cuproptosis as a potential factor in IHF pathogenesis and immune response.