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Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age
Walter Maetzler1, Leonor Correia Guedes2, Kirsten Nele Emmert1
1Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Digital Biomarkers
|March 21, 2024
Summary
Digital wearable technologies offer objective ways to measure fatigue-related changes in daily function, moving beyond subjective questionnaires. Key parameters like physical activity and mobility show promise for quantitative fatigue assessment in various diseases.
Area of Science:
- Biomedical Engineering
- Digital Health
- Clinical Research
Background:
- Fatigue significantly impairs daily function across many diseases.
- Current methods for measuring daily function rely on subjective and imprecise questionnaires.
- Digital wearable technologies enable objective, quantitative assessment of daily function in real-world settings.
Purpose of the Study:
- To identify digitally assessable parameters reflecting fatigue-related changes in daily function.
- To focus on immune-mediated inflammatory and neurodegenerative diseases.
Main Methods:
- Standardized literature analysis of perception-, capacity-, and performance-evaluating assessment tools.
- Identification of parameters with the highest potential to reflect fatigue-related changes.
Main Results:
- Physical activity, independence in daily living, social participation, working life, mental status, cognitive and aerobic capacity, and mobility performance are key parameters.
- These parameters demonstrate high potential for reflecting fatigue-related functional changes.
Conclusions:
- These identified parameters hold significant potential for quantitative fatigue measurement using digital wearable technologies in real-life conditions.
- This approach offers a novel framework for designing digital assessment protocols in human research, potentially stimulating further investigation.
