NT-proBNP in patients presenting with myocardial infarction and non-obstructive coronary arteries without left...

Area of Science:

• Cardiology
• Biomarkers
• Acute Coronary Syndromes

Background:

• Myocardial infarction with non-obstructive coronary arteries (MINOCA) affects a significant portion of acute coronary syndrome patients.
• Currently, no evidence-based therapy exists for MINOCA.
• NT-proBNP is a known prognostic biomarker in heart failure and ischemic heart disease, but its utility in MINOCA is understudied.

Purpose of the Study:

• To investigate the diagnostic and clinical utility of NT-proBNP measurement in MINOCA patients.
• To assess the association of NT-proBNP levels with clinical outcomes in MINOCA without left ventricular dysfunction or heart failure.

Main Methods:

• Prospective study involving patients diagnosed with MINOCA post-coronary angiography.
• Collection of demographic data, left ventricular function via echocardiography, and NT-proBNP levels from blood samples.
• Prospective follow-up of patient outcomes, including hospital readmissions and mortality.

Main Results:

• Fifty-five MINOCA patients with ejection fraction >40% were included; NT-proBNP was available in 87%.
• A median NT-proBNP of 312 pg/mL was observed.
• 40% of patients were readmitted post-discharge, with NT-proBNP ≥125 pg/mL significantly associated with rehospitalization (P=0.02).

Conclusions:

• NT-proBNP ≥125 pg/mL was identified in 72% of MINOCA patients with preserved ejection fraction.
• Elevated NT-proBNP levels are associated with an increased risk of rehospitalization in this population.