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Updated: Jun 30, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Light-Driven Photocatalyst-Free Synthesis of β, δ-Functionalized Ketones from Aldehydes
Quansheng Mou1, Tongyu Han1, Miao Tian1
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Abstract:
The synthesis of ketones has been a long focus of chemistry research, on account of its unique reactivity. Herein, we report a simple light-driven photocatalyst-free synthesis of β, δ-functionalized ketones from aldehydes, using inexpensive and commercially abundant feedstock chemicals. This reaction is enabled by the direct acyl radical generation via hydrogen atom transfer and the subsequent radical addition process, avoiding the need for prefunctionalized substrates and organometallic reagent.
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