Related Experiment Video
Updated: Jun 30, 2025

08:42
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
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[Recurrent depressive disorder associated with an atypical CADASIL syndrome]
Tijdschrift Voor Psychiatrie
|March 21, 2024
Summary
Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) may be underdiagnosed in patients with recurrent depression. Atypical presentations, including depression without typical stroke history, warrant consideration of genetic testing for NOTCH3 mutations.
Area of Science:
- Neurology
- Genetics
- Psychiatry
Background:
- Recurrent depressive episodes can be debilitating, impacting patient prognosis and treatment.
- Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic disorder often associated with stroke and cognitive decline.
- While depression is a known symptom in CADASIL, atypical presentations are increasingly recognized.
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