Related Experiment Video

Updated: Jul 11, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
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Published on: November 23, 2013

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[Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties]

S Wouters, K Van Laere, F-L De Winter

    Tijdschrift Voor Psychiatrie
    |April 23, 2024
    PubMed

    Insights

    Anti-NMDA receptor encephalitis, an autoimmune disorder, often mimics psychiatric conditions, delaying diagnosis. Early detection is crucial for better outcomes in patients with this complex neurological disease.

    Area of Science:

    • Neurology
    • Immunology
    • Psychiatry

    Background:

    • Autoimmune encephalitis targeting N-methyl-D-aspartate (NMDA) receptors is a significant cause of neurological and psychiatric morbidity.
    • Early diagnosis is frequently challenging due to non-specific and heterogeneous presenting symptoms.

    Observation:

    • A case of anti-NMDA receptor encephalitis is presented, initially misdiagnosed as psychotic depression.
    • Neurological manifestations were misinterpreted as psychiatric symptoms or treatment side effects.

    Findings:

    • The study highlights the diagnostic difficulties in anti-NMDA receptor encephalitis, particularly when psychiatric symptoms dominate.
    • A comprehensive diagnostic approach is essential to identify this treatable neurological condition.

    Implications:

    • This case underscores the importance of considering autoimmune encephalitis in patients with unexplained or treatment-resistant neuropsychiatric disorders.
    • Timely diagnosis and treatment of anti-NMDA receptor encephalitis can significantly improve patient prognosis and reduce long-term disability.

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