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Increasing Annual Cancer Incidence in Patients Age 20-49 Years: A Real-Data Study
Nuria Ribelles1, Javier Pascual1,2, Laura Galvez-Carvajal1
1Medical Oncology Intercenter Unit, Regional and Virgen de la Victoria University Hospitals, IBIMA, Malaga, Spain.
JCO Global Oncology
|March 21, 2024
Summary
Cancer incidence is rising in younger populations, with early-onset cancers showing a higher increase than late-onset cancers for several tumor types. This trend highlights a growing public health concern requiring attention.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Population-based studies indicate rising incidence of specific neoplasms in individuals under 50 years (early-onset cancer, EOC).
- Limited real-world data exists on trends in early-onset cancer (EOC) incidence.
- This study investigates changes in neoplasm incidence across generations using a non-population registry.
Purpose of the Study:
- To analyze changes in the incidence of various neoplasms in successive generations.
- To compare the incidence trends of early-onset cancer (EOC) versus late-onset cancer (LOC) in a real-world setting.
Main Methods:
- A cross-sectional study analyzed 18 neoplasms diagnosed between 1998 and 2021 at a Spanish university hospital.
- Proportions of EOC (<50 years) and LOC (≥50 years) were determined annually.
- Annual Percentage Change (APC) and Average APC (AAPC) were calculated to assess incidence trends.
Main Results:
- The study included 24,596 patients: 22.2% with EOC and 77.8% with LOC.
- Overall tumor incidence increased in both EOC and LOC groups.
- AAPC increases were significantly higher for EOC than LOC in head and neck, colon, testicular, non-Hodgkin lymphoma, rectum, kidney, and sarcoma.
Conclusions:
- Findings align with existing data on increasing early-onset cancer (EOC) incidence.
- The rising incidence of EOC is a significant global public health issue.
- Urgent attention is needed to address and mitigate the increase in cancer among younger populations.
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