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Updated: Jun 30, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Copper-catalyzed synthesis of primary amides through reductive N-O cleavage of dioxazolones
Hyeonwoong Bae1,2, Jinhwan Park1,2, Rahyun Yoon2
1Department of Chemical Engineering (BK21 FOUR Graduate Program), Dong-A University 37 Nakdong-Daero 550beon-gil, Saha-gu Busan 49315 South Korea sonorganic@dau.ac.kr.
Abstract:
A new method for the synthesis of primary amides is developed, in which dioxazolones are treated with a copper catalyst under mild reaction conditions. A broad scope of dioxazolones is exhibited as well as dioxazolones containing biologically active structural motifs. These robust and mild reaction conditions allow the transformation of dioxazolones to primary amides, in which sensitive functional groups such as hydroxyl, aldehyde, trialkylsilyl, and unsaturated carbon units are tolerated with excellent chemoselectivity.
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