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Published on: February 15, 2016
Induced Chirality in Canthaxanthin Aggregates Reveals Multiple Levels of Supramolecular Organization
Monika Halat1, Grzegorz Zając2, Valery Andrushchenko3
1Department of Plant Biology and Biotechnology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120, Krakow, Poland.
Abstract:
Carotenoids tend to form supramolecular aggregates via non-covalent interactions where the chirality of individual molecules is amplified to the macroscopic level. We show that this can also be achieved for non-chiral carotenoid monomers interacting with polysaccharides. The chirality induction in canthaxanthin (CAX), caused by heparin (HP) and hyaluronic acid (HA), was monitored by chiroptical spectroscopy. Electronic circular dichroism (ECD) and Raman optical activity (ROA) spectra indicated the presence of multiple carotenoid formations, such as H- and J-type aggregates. This is consistent with molecular dynamics (MD) and density functional theory (DFT) simulations of the supramolecular structures and their spectroscopic response.
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