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Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice
Allison L Fisher1, Sydney Phillips1, Chia-Yu Wang1
1Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Blood
|March 22, 2024
Abstract:
Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions.

