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Cilia and Nodal Flow in Asymmetry: An Engineering Perspective
Madisyn Messmore1, Alain J Kassab2, Ray O Prather3
1University of Central Florida.
Critical Reviews in Biomedical Engineering
|March 25, 2024
Summary
Cilia in the primitive node are crucial for determining the left-right body axis during embryonic development. Their motion influences fluid dynamics, and disruptions can lead to developmental disorders.
Area of Science:
- Developmental Biology
- Biomedical Engineering
- Biophysics
Background:
- Cilia in the primitive node play a critical role in establishing the left-right axis during embryonic development.
- The precise mechanisms by which nodal cilia influence axis determination are still being investigated.
- Disruptions in cilia function are linked to various health issues, including congenital heart disease and infertility.
Conclusions:
- Understanding nodal cilia function is vital for comprehending embryonic development and associated disorders.
- Interdisciplinary collaboration is encouraged to advance research in this field.
- Further investigation into cilia mechanics and fluid dynamics may reveal new therapeutic targets.
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