Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell-matrix's Response to Mechanical Forces

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PIEZO mechanosensitivity in chondrocytes is differentially modulated by L-type and T-type voltage-sensitive ion channels.

Osteoarthritis and cartilage open·2025

Same author

Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025

Same author

Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes.

Proceedings of the National Academy of Sciences of the United States of America·2023

Same author

Mechanogenetics: harnessing mechanobiology for cellular engineering.

Current opinion in biotechnology·2021

Same author

Immunoengineering the next generation of arthritis therapies.

Acta biomaterialia·2021

Same author

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.

Proceedings of the National Academy of Sciences of the United States of America·2021

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Reactive Constrained Mixtures for Modeling the Solid Matrix of Biological Tissues.

Robert J Nims¹, Gerard A Ateshian¹

¹Columbia University, 500 West 120th St, MC4703, New York, NY 10027, USA.

Journal of Elasticity

|March 25, 2024

Summary

This study presents a unified framework for modeling biological tissues using reactive constrained mixtures. This approach integrates mechanics and chemical kinetics to simulate tissue growth, remodeling, and viscoelastic behavior.

Keywords:

Biomechanics Growth and remodeling Mixture theory Reactive mixtures Viscoelasticity

More Related Videos

Finite Element Modelling of a Cellular Electric Microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Author Spotlight: Patient-Informed 3D Model for Studying Glioblastoma Invasion via Interstitial Fluid Flow

Author Spotlight: Patient-Informed 3D Model for Studying Glioblastoma Invasion via Interstitial Fluid Flow

Published on: October 18, 2024

Related Experiment Videos

Last Updated: Jul 1, 2026

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Finite Element Modelling of a Cellular Electric Microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Author Spotlight: Patient-Informed 3D Model for Studying Glioblastoma Invasion via Interstitial Fluid Flow

Author Spotlight: Patient-Informed 3D Model for Studying Glioblastoma Invasion via Interstitial Fluid Flow

Published on: October 18, 2024

Area of Science:

Continuum mechanics
Biomaterials science
Chemical kinetics

Background:

Biological tissues exhibit complex mechanical and chemical properties.
Existing models often struggle to capture the interplay between mechanics and chemical processes in tissues.

Purpose of the Study:

To introduce a unified modeling framework for biological tissues using reactive constrained mixtures.
To demonstrate the integration of mechanics and chemical kinetics for tissue modeling.

Main Methods:

Development of reactive constrained mixture models.
Application of the framework to simulate fibrous material behavior.
Modeling of tissue growth, remodeling, and viscoelasticity through chemical reactions.

Main Results:

The framework successfully recovers classical theories for fibrous materials.
Demonstrated ability to model anisotropic changes due to tissue growth and remodeling.
Successfully modeled free energy dissipation in viscoelastic materials.

Conclusions:

Reactive constrained mixtures provide an elegant and unified approach to modeling biological tissues.
This framework effectively links mechanics and chemical kinetics for comprehensive tissue simulation.
The approach is well-suited for diverse applications in biomaterials and tissue engineering.