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Related Experiment Video

Updated: Jun 29, 2025

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

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BioCloneBot: A versatile, low-cost, and open-source automated liquid handler.

Ke'Koa Cdh Wells1, Nawwaf Kharma1,2, Brandon B Jaunky2

  • 1Department of Electrical and Computer Engineering, Concordia University, Montréal, Québec, Canada.

Hardwarex
|March 25, 2024
PubMed
Summary
This summary is machine-generated.

Researchers can now automate liquid handling with BioCloneBot, a low-cost, open-source system built from 3D-printed parts. This affordable automated liquid handler makes lab automation accessible for diverse research and diagnostic applications.

Keywords:
3D printingDNA cloningLiquid handlerOpen-sourceSynthetic biology

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Area of Science:

  • Biotechnology
  • Laboratory Automation
  • Open-Source Hardware

Background:

  • Automated liquid handler systems offer significant laboratory benefits but are often prohibitively expensive.
  • High costs create a barrier to entry for many researchers and institutions.
  • Need for accessible and customizable automation solutions in scientific research.

Purpose of the Study:

  • Introduce BioCloneBot, a versatile, low-cost, open-source automated liquid handler.
  • Demonstrate the feasibility of building an automated liquid handler using 3D-printed parts and commercial components.
  • Provide a customizable platform to address diverse liquid handling needs in research and diagnostics.

Main Methods:

  • Design and construction of the BioCloneBot using 3D-printed components and readily available commercial parts.
  • Development of a user-friendly interface and programmable control system.
  • Validation of the system's performance through various liquid handling tasks, assessing precision, accuracy, and repeatability.

Main Results:

  • Successful construction and validation of the BioCloneBot, demonstrating precise, accurate, and repeatable liquid handling.
  • BioCloneBot proves to be a versatile and adaptive system suitable for a wide range of applications.
  • The open-source nature facilitates customization and collaboration among researchers.

Conclusions:

  • BioCloneBot offers a cost-effective solution for laboratory automation, overcoming financial barriers.
  • The system empowers researchers to streamline liquid handling processes, enhancing experimental throughput.
  • Open-source accessibility promotes innovation and adaptation of automated liquid handling technology in scientific communities.