Associations between inflammatory and angiogenic proteomic biomarkers, and cardiovascular events and mortality in...

Area of Science:

• Cardiovascular Medicine
• Nephrology
• Proteomics

Background:

• The relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD) burden is not fully understood.
• Investigating inflammatory and angiogenic biomarkers in acute coronary syndrome (ACS) patients is crucial.
• Understanding how CKD influences these associations is key.

Purpose of the Study:

• To explore associations between biomarkers, kidney function, and outcomes in ACS patients.
• To determine if CKD status modifies the link between biomarkers and major adverse cardiovascular events plus death (MACE+).

Main Methods:

• 1293 ACS patients were followed for long-term outcomes.
• 13 pre-identified biomarkers were analyzed using proteomic methods.
• Cox regression models assessed biomarker associations with MACE+ and CKD interaction.

Main Results:

• Nine biomarkers showed inverse associations with kidney function.
• Endothelial cell-specific molecule-1 (ESM-1), FGF-23, and transmembrane immunoglobulin 1 (TIM-1) were linked to MACE+.
• Only FGF-23 remained independently associated with MACE+; no biomarkers interacted with CKD.

Conclusions:

• Nine of 13 biomarkers increased as kidney function declined.
• FGF-23 independently predicted MACE+ in ACS patients, irrespective of CKD.
• FGF-23 is a significant prognostic marker for ACS patients with or without CKD.