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Updated: Jun 29, 2025

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Downregulation of INPP4B is Associated with Poor Prognosis in Epithelial Ovarian Carcinoma

Liangliang Jiang1, Jing Wang1

  • 1Department of Gynecological Tumor, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.

International Journal of General Medicine
|March 25, 2024
PubMed
Abstract

Insights

Inositol polyphosphate-4-phosphatase type II (INPP4B) is downregulated in epithelial ovarian cancer, correlating with poor prognosis. This downregulation may drive cancer progression and chemotherapy insensitivity.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Inositol polyphosphate-4-phosphatase type II (INPP4B) is a tyrosine-specific phosphatase implicated in carcinogenesis.
  • The role of INPP4B in epithelial ovarian cancer (EOC) remains underexplored.

Purpose of the Study:

  • To investigate INPP4B expression in EOC and normal ovaries.
  • To correlate INPP4B expression with clinicopathological factors and patient prognosis in EOC.

Main Methods:

  • Bioinformatics analysis of INPP4B expression in various tumors.
  • ELISA for INPP4B detection in EOC and normal ovarian tissues.
  • Immunohistochemistry on 100 EOC and 20 normal ovarian specimens.
  • Correlation analysis with clinicopathological factors and survival.

Main Results:

  • INPP4B protein expression was significantly lower in EOC compared to normal ovaries (P < 0.05).
  • INPP4B expression correlated significantly with tumor differentiation, FIGO stage, lymph node metastasis, and distant metastasis at recurrence (all P < 0.001).
  • No significant association was found with age, tumor type, CA125 levels, or chemotherapy sensitivity.

Conclusions:

  • Downregulation of INPP4B in EOC is associated with poor differentiation, advanced stage, metastasis, and potentially chemotherapy insensitivity.
  • Under-expression of INPP4B, along with metastasis and advanced stage, are indicators of poor prognosis.
  • Reduced INPP4B expression may contribute to the progression of epithelial ovarian carcinoma.
Keywords:
INPP4Bepithelial ovarian carcinomaimmunohistochemistry: clinical significancesurvival

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