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Maxam-Gilbert Sequencing

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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Programming sp³ Quantum Defects along Carbon Nanotubes with Halogenated DNA.

Xiaojian Wu¹, Mijin Kim^1,2, Lucy J Wang¹

¹Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.

Journal of the American Chemical Society

|March 25, 2024

Summary

We developed a DNA-guided method to precisely create quantum defects on carbon nanotubes. This breakthrough enables controlled placement of these defects for advanced quantum technologies.

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Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

Area of Science:

Quantum Materials Science
Nanotechnology
Photochemistry

Background:

Atomic defects in solids are crucial for quantum technologies.
Fabricating high-quality, densely packed defects remains a challenge.

Purpose of the Study:

To introduce a DNA-programmable photochemical method for creating quantum defects on semiconducting single-walled carbon nanotubes (SWCNTs).
To demonstrate precise control over defect placement and properties.

Main Methods:

Utilizing DNA strands with strategically substituted halogenated uracil, wrapped around SWCNTs.
Employing photochemical activation to form sp³ defects, acting as deep exciton traps.
Modifying DNA spacers to control defect positioning along the nanotube.

Main Results:

Successful creation of organic color-center quantum defects on SWCNTs.
Observed a significant photoluminescence shift (191 meV for (6,5)-SWCNTs) due to deep exciton trapping.
Achieved systematic control over defect placement by adjusting DNA spacers.

Conclusions:

This DNA-programmable photochemical approach offers a precise way to engineer quantum defects on SWCNTs.
The method bridges molecular chemistry and quantum materials science for fabricating tailored quantum defects.
Represents a significant advancement for applications in quantum information science, imaging, and sensing.