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Related Experiment Video

Updated: Jun 29, 2025

Isolation, Processing and Analysis of Murine Gingival Cells

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

Biological Processes in Gingival Tissue Integration Around Dental Implants.

Jing Han¹, Sander C G Leeuwenburgh¹, John A Jansen¹

¹Department of Dentistry-Regenerative Biomaterials, Research Institute for Medical Innovation, Radboudumc, Nijmegen, The Netherlands.

Tissue Engineering. Part B, Reviews

|March 25, 2024

Summary

This review examines in vitro models for assessing dental implant gingival tissue integration (GTI). It evaluates different models to improve understanding and predictability of soft tissue healing around implants.

Keywords:

dental implant gingival tissue integration in vitro model

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Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

Area of Science:

Biomaterials Science
Dental Implantology
Tissue Engineering

Background:

Peri-implant gingival tissue integration (GTI) is crucial for dental implant longevity and function.
Research has shifted focus towards understanding soft tissue responses to implant surfaces.
Existing in vitro and in vivo models for assessing GTI show inconsistent outcomes, necessitating a comprehensive review.

Purpose of the Study:

To provide a comprehensive overview of 2D and 3D in vitro models for investigating cellular behavior relevant to peri-implant GTI.
To elucidate the histological characteristics of gingival tissues around natural dentition and their adaptation to implants.
To critically evaluate the strengths and limitations of current in vitro models for GTI research.

Main Methods:

Literature review of existing in vitro models (2D and 3D) for peri-implant GTI.
Analysis of histological characteristics of gingival tissues adjacent to natural teeth and dental implants.
Critical evaluation of the strengths and limitations of various in vitro models.

Main Results:

Overview of diverse in vitro models, from 2D to 3D, used in GTI research.
Insights into gingival tissue healing dynamics and histological adaptation processes.
Identification of strengths and limitations of each model, aiding in applicability assessment.

Conclusions:

A comprehensive understanding of in vitro models is needed to improve the predictability of peri-implant GTI.
Evaluating model strengths and limitations is essential for effective GTI research.
This review aims to enhance the understanding and application of in vitro models in dental implantology.