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Articles linked to this work by shared authors, journal, and citation graph.

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Lactation Interrupted: PFAS Impact on Capacity to Breastfeed Ignored.

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Related Experiment Video

Updated: Jun 29, 2025

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique
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Public Health Risks of PFAS-Related Immunotoxicity Are Real.

Abigail P Bline1,2, Jamie C DeWitt3, Carol F Kwiatkowski4

  • 1Social Science Environmental Health Research Institute, Northeastern University, Boston, MA, 02115, USA. a.bline@northeastern.edu.

Current Environmental Health Reports
|March 25, 2024
PubMed
Summary
This summary is machine-generated.

Per- and polyfluoroalkyl substances (PFAS) exposure is linked to reduced vaccine response. Current regulations fail to adequately incorporate PFAS immunotoxicity data, risking public health. We recommend using all immunotoxicity data for better risk assessment and clinical guidance.

Keywords:
Clinical guidanceImmunosuppressionPer- and polyfluoroalkyl substancesPopulation healthRisk assessmentVaccine

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Area of Science:

  • Environmental Health
  • Toxicology
  • Immunology

Background:

  • Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants.
  • Growing concern exists regarding adverse health effects from PFAS exposure.
  • Immunotoxicity is a key area of concern for PFAS.

Purpose of the Study:

  • To review the application of PFAS immunotoxicity data in regulatory and clinical decision-making.
  • To assess whether current public health decisions adequately consider PFAS immunotoxicity.
  • To advocate for improved integration of immunotoxicity data in PFAS risk assessment and regulation.

Main Methods:

  • Review of existing government and academic literature on PFAS immunotoxicity.
  • Analysis of recent regulatory and clinical decision-making processes concerning PFAS.
  • Evaluation of the incorporation of immunotoxicity data in these processes.

Main Results:

  • The strongest human evidence links PFAS exposure to reduced antibody production following vaccination (e.g., tetanus, diphtheria).
  • Recent regulatory and clinical recommendations appear to inadequately incorporate this critical immunotoxicity data.
  • A gap exists between scientific findings on PFAS immunotoxicity and their application in public health policy.

Conclusions:

  • Current PFAS risk assessment and regulation must more effectively utilize all available immunotoxicity data.
  • Biological markers of immune effects, like reduced vaccine antibody response, should be standard for assessing PFAS health risks.
  • Clinical guidance for PFAS-exposed populations needs strengthening to include immune system monitoring and protective actions.