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Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Nucleotide Excision Repair01:38

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DNA Distortion and Damage
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Updated: Jun 29, 2025

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

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Gene Therapy for Skin Aging.

Fawzy A Saad1

  • 1Department of Gene Therapy, Saad Pharmaceuticals, Juhkentali 8, Tallinn, 10132, Estonia.

Current Gene Therapy
|March 26, 2024
PubMed
Summary
This summary is machine-generated.

Skin aging gene therapy offers potential for rejuvenation and restoring natural beauty. This advanced approach aims to reverse biological aging, paving the way for the emerging genecosmetics era.

Keywords:
Geneagingextrinsicgenecosmeticsintrinsicmitochondrial dysfunction.therapy

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Last Updated: Jun 29, 2025

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Area of Science:

  • Dermatology and Genetics
  • Aging Research
  • Aesthetic Medicine

Background:

  • Skin aging is influenced by both external (extrinsic) and internal (intrinsic) factors.
  • Intrinsic skin aging reflects systemic age-related bodily decline, with skin appearance indicating overall health.
  • Previously considered unalterable, intrinsic aging factors are now being targeted by emerging gene therapies.

Purpose of the Study:

  • To explore the potential of gene therapy for skin rejuvenation and restoration of natural beauty.
  • To discuss the application of gene therapy in treating skin diseases.
  • To highlight the future prospects of genocosmetics and healthy aging.

Main Methods:

  • Focuses on the concept of skin aging gene therapy, including telomere extension via telomerase stimulation.
  • Discusses the potential for reversing biological aging processes.
  • Considers the integration of lifestyle factors like caloric restriction and exercise.

Main Results:

  • Skin aging gene therapy presents a novel approach to combatting aging.
  • It offers tools for rejuvenation, beauty restoration, and disease treatment.
  • Potential to significantly impact aesthetic medicine and healthy aging.

Conclusions:

  • Skin aging gene therapy holds promise for reversing biological aging and promoting longevity.
  • The development of genocosmetics is anticipated.
  • This field offers a path towards a 'fountain of youth' for aesthetic and health benefits.