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An Injectable Magnesium-Based Cement Stimulated with NIR for Drug-Controlled Release and Osteogenic Potential
Yanbin Zhao1, Yangyang Li1, Bin Wang2
1School of Materials Science and Engineering, Jiangsu Key Laboratory for Advanced Metallic Materials, Southeast University, Nanjing, 211189, China.
Advanced Healthcare Materials
|March 26, 2024
Summary
This study developed a smart injectable magnesium phosphate bone cement (MPC) for orthopedic implants. The novel material offers controlled drug release, enhanced bone growth, and antibacterial properties, improving clinical applications.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Drug Delivery Systems
Background:
- Magnesium phosphate bone cement (MPC) is widely used in orthopedics for its rapid setting and high initial strength.
- Achieving controlled drug release and osteogenic potential simultaneously in MPC presents a significant challenge for advanced orthopedic applications.
Purpose of the Study:
- To develop a smart, injectable bone cement system incorporating nanocontainers for controlled drug release and enhanced osteogenic potential.
- To engineer a magnesium phosphate bone cement (MPC) with near-infrared (NIR) responsive drug delivery and improved biological functions.
Main Methods:
- Fabrication of nanocontainers with alendronate-loaded mesoporous silica nanoparticles, surface-modified with polypyrrole for NIR-triggered release.
- Incorporation of these nanocontainers into magnesium phosphate bone cement (MPC) to create alendronate-incorporated cement (ACMPC).
- Evaluation of mechanical properties (compressive strength, setting time, injectability), degradation resistance, antibacterial activity, biocompatibility, and osteogenic potential of the ACMPC.
Main Results:
- The developed alendronate-incorporated cement (ACMPC) demonstrated improved compressive strength (70.6 ± 5.9 MPa), prolonged setting time (913 s), and excellent injectability.
- NIR irradiation triggered controlled alendronate release, conferring antibacterial properties via hyperthermia, reactive oxygen species, and the drug itself.
- The ACMPC exhibited good biocompatibility and significantly promoted osteogenesis, evidenced by increased alkaline phosphatase activity, matrix mineralization, and osteogenic gene expression.
Conclusions:
- The proposed smart injectable cement system effectively integrates controlled drug delivery, enhanced mechanical properties, antibacterial efficacy, and osteogenic potential.
- This multifunctional biomaterial holds significant promise for advanced orthopedic implantation and clinical applications, addressing limitations of conventional bone cements.
