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Related Experiment Video

Updated: Jun 29, 2025

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays

Published on: May 3, 2024

High-spatial-resolution transcranial focused ultrasound neuromodulation using frequency-modulated pattern

Young Hun Kim¹, Ki Chang Kang², Jeong Nyeon Kim³

¹Mechanical Convergence Engineering, Hanyang University, Seoul 04763, Republic of Korea; Edward. L. Ginzton Lab, Stanford University, Stanford, CA 94305, USA.

|March 26, 2024

Summary

This summary is machine-generated.

This study introduces a novel neuromodulation system using frequency-modulated pattern interference radiation force (FM-PIRF) to enhance precision in brain stimulation. The new method achieves superior spatial resolution and electronic control for targeted ultrasound neuromodulation.

Keywords:

Frequency Modulation Pattern Interference Radiation Force Spatial Resolution Ultrasound Neuromodulation

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Published on: September 6, 2024

Area of Science:

Neuroscience
Biomedical Engineering
Acoustics

Background:

Precise brain stimulation is essential for ultrasound neuromodulation.
Transcranial focused ultrasound faces challenges in achieving high spatial resolution.
Existing methods struggle with targeting accuracy in neuromodulation.

Purpose of the Study:

To present a novel neuromodulation system overcoming current limitations in spatial resolution and targeting.
To introduce a method utilizing acoustic radiation force with frequency-modulated waveforms and standing waves.
To demonstrate enhanced axial spatial resolution and electronic control in ultrasound neuromodulation.

Main Methods:

Development of a neuromodulation system based on acoustic radiation force.
Implementation of a frequency-modulated pattern interference radiation force (FM-PIRF) technique.
Utilizing a linear frequency-modulated chirp waveform and measuring cantilever displacement to visualize radiation force distribution.

Main Results:

Achieved axial spatial resolution at a single wavelength level.
Demonstrated electronic control of the target location in the axial direction.
Experimentally validated the improved spatial resolution and electrical movement capabilities of FM-PIRF.

Conclusions:

The FM-PIRF technique significantly enhances spatial resolution in ultrasound neuromodulation.
The developed system offers precise, electronically controllable targeting for brain stimulation.
This advancement holds potential for more effective non-invasive brain interventions.