Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

56
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
56
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

98
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
98
Sex-linked Disorders01:43

Sex-linked Disorders

102.1K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.1K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.4K
Alternative RNA Splicing02:18

Alternative RNA Splicing

21.1K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.1K
Genetic Lingo01:11

Genetic Lingo

102.7K
Overview
102.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prefrontal Circuitry Abnormalities and Cognitive Impairment in Adolescents with Early- Onset Psychosis.

Research square·2026
Same author

Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

Molecular psychiatry·2026
Same author

Synaptic and Circuit Mechanisms Shaping Neurodevelopmental and Psychiatric Outcomes Associated with 16p11.2 Copy Number Variation.

Genes·2026
Same author

Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Youth.

medRxiv : the preprint server for health sciences·2026
Same author

Using EEG to Measure the Neural Effects of Oxytocin Administration: A Meta-Analysis and Systematic Review.

Psychophysiology·2026
Same author

Gene × sex interactions on cognition in the Philadelphia neurodevelopmental cohort.

Biology of sex differences·2026

Related Experiment Video

Updated: Jun 29, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.0K

Using rare genetic mutations to revisit structural brain asymmetry.

Jakub Kopal1,2, Kuldeep Kumar3, Kimia Shafighi1,2

  • 1Mila - Québec Artificial Intelligence Institute, Montréal, QC, Canada.

Nature Communications
|March 27, 2024
PubMed
Summary
This summary is machine-generated.

Rare genetic deletions and duplications significantly impact brain asymmetry, affecting functions like language and facial recognition. This study reveals how specific gene sets influence brain lateralization and human cognition.

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.6K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K

Related Experiment Videos

Last Updated: Jun 29, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.0K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.6K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K

Area of Science:

  • Neurogenetics
  • Cognitive Neuroscience
  • Human Genetics

Background:

  • Brain organization features hemispheric asymmetry, crucial for advanced cognitive functions like language and facial recognition.
  • Previous genetic studies on brain asymmetry primarily used common variants with minor effects.
  • Rare genomic deletions and duplications offer a powerful tool to investigate genetic impacts on brain structure and function.

Purpose of the Study:

  • To dissect the impact of high-effect-size copy number variations (CNVs) on human brain asymmetry.
  • To explore the relationship between genetic alterations, brain lateralization, and behavior.
  • To identify specific gene sets influencing brain asymmetry and cognitive functions.

Main Methods:

  • A pattern-learning approach was employed to analyze brain asymmetry in a large cohort.
  • Included 552 copy number variation (CNV) carriers and 290 non-carriers across multiple sites.
  • Utilized genome-wide association study (GWAS) for targeted analysis of common variants.

Main Results:

  • Multivariate brain asymmetry patterns were identified, highlighting regions involved in lateralized functions (language, hearing, visual, face, word recognition).
  • Planum temporale asymmetry was particularly sensitive to deletions and duplications of specific gene sets.
  • Genetic influences on right versus left planum temporale structure were partly divergent.

Conclusions:

  • Genetically controlled brain lateralization has significant consequences for uniquely human cognitive capacities.
  • Rare genomic variations provide insights into the genetic architecture of brain asymmetry.
  • Gene-brain-behavior data fusion illuminates the role of lateralization in cognition.