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A Nomogram for Predicting the Risk of Deep Vein Thrombosis in Patients With Acute Ischemic Stroke During the COVID-19

Jie Zhang1, Shurui Zhang2, Ge Song1

  • 1Neuroscience Center, Department of Neurology, First Hospital of Jilin University, Changchun, China.

Angiology
|March 27, 2024
PubMed

Insights

The risk of deep vein thrombosis (DVT) in stroke patients increased during the COVID-19 pandemic. A new nomogram helps predict DVT risk in stroke patients during long-term COVID-19 management.

Area of Science:

  • Neurology
  • Cardiology
  • Infectious Diseases

Background:

  • Deep vein thrombosis (DVT) is a significant complication following stroke.
  • The COVID-19 pandemic necessitates re-evaluation of DVT management in stroke patients.
  • Understanding DVT risk factors during the COVID-19 era is crucial for long-term patient care.

Purpose of the Study:

  • To assess the risk of DVT in stroke patients during the COVID-19 pandemic compared to pre-pandemic periods.
  • To identify significant risk factors associated with DVT in stroke patients during COVID-19.
  • To develop and validate a predictive nomogram for DVT in stroke patients during long-term COVID-19 management.

Main Methods:

  • Retrospective analysis of 7087 stroke patients during the COVID-19 period and 14,174 matched patients from before the pandemic.
  • Comparison of DVT incidence rates between the two periods.
  • Statistical analysis to identify predictors of DVT and construction of a predictive nomogram with internal and external validation.

Main Results:

  • The incidence of DVT in stroke patients was significantly higher during the COVID-19 period (20.5%) compared to the pre-pandemic period (15.9%).
  • Key predictors of DVT included age, body mass index, smoking, D-dimer levels, physical activity, NIHSS score, and use of intermittent pneumatic compression.
  • The developed nomogram demonstrated high accuracy and clinical applicability in predicting DVT risk.

Conclusions:

  • Stroke patients faced an elevated risk of DVT during the COVID-19 pandemic.
  • The established nomogram provides a valuable tool for assessing and predicting DVT risk in stroke patients during the ongoing management of COVID-19.
  • Early DVT risk assessment and prevention strategies are essential for stroke survivors during the COVID-19 era.

Keywords:
COVID-19deep vein thrombosisnomogramstroke

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