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LncRNA H19: A Novel Biomarker in Cardiovascular Disease

Xiaojun Li1, Yugui Zhang2, Zhaoran Ding3

  • 1Basic Medical College.

Acta Cardiologica Sinica
|March 27, 2024
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial in cardiovascular disease development. This review highlights the role of lncRNA H19 in heart conditions, suggesting its potential as a future therapeutic target.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) are leading global causes of mortality.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in CVD pathogenesis.
  • lncRNA H19 is a notable molecule implicated in various cardiovascular conditions.

Purpose of the Study:

  • To comprehensively review the involvement of lncRNA H19 in cardiovascular diseases.
  • To elucidate the pathophysiological mechanisms of lncRNA H19 in heart diseases.
  • To establish a foundation for lncRNA H19 as a potential therapeutic target for CVDs.

Main Methods:

  • Literature review of studies on lncRNA H19 and cardiovascular diseases.
  • Analysis of experimental data linking lncRNA H19 to cardiac pathophysiology.
  • Synthesis of current knowledge on lncRNA H19's regulatory functions in the heart.

Main Results:

  • lncRNA H19 is implicated in diverse cardiovascular diseases, including atherosclerosis and cardiomyopathy.
  • Evidence suggests lncRNA H19 actively participates in the molecular processes underlying heart disease.
  • lncRNA H19 exhibits regulatory roles in various cardiovascular pathophysiological events.

Conclusions:

  • lncRNA H19 plays a significant role in the development and progression of cardiovascular diseases.
  • Understanding lncRNA H19's functions offers insights into novel therapeutic strategies for heart conditions.
  • lncRNA H19 represents a promising target for future cardiovascular disease treatments.

Keywords:
Cardiovascular diseaseLncRNA H19Novel biomarker

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