Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Brassinosteroids define the stem elongation zone along the apical-basal axis to coordinate gravitropism and self-standability.

Plant physiology·2026

Same author

Association between adverse childhood experiences and over-the-counter drug abuse in Japan: A nationwide population-based cross-sectional study.

PCN reports : psychiatry and clinical neurosciences·2026

Same author

Association between maternal bonding difficulty and neurodevelopmental delay in children aged 2 to 4 years: the Japan Environment and Children's Study.

Journal of developmental origins of health and disease·2026

Same author

The Safety and Efficacy of a Transbronchial Lung Cryobiopsy Using a 1.7-mm Cryoprobe in Older Adult Patients with Suspected Interstitial Lung Disease: A Single-center, Retrospective, Observational Study.

Internal medicine (Tokyo, Japan)·2026

Same author

Management of Airway Foreign Bodies Caused by Dental Prostheses Complicated by Obstructive Pneumonia: A Report of Two Cases.

Respirology case reports·2026

Same author

Safe Bronchoscopic Treatment Strategy for Subglottic Severe Airway Stenosis: A Case Report of Tracheal MALT Lymphoma.

Respirology case reports·2026

Search research articles

Related Experiment Video

Updated: May 1, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

Granulocyte-Colony Stimulating Factor (G-CSF)-Induced Aortitis: A Case Report.

Masahiro Ito¹, Masakazu Amari¹, Akiko Sato¹

¹Breast Surgery, Tohoku Kosai Hospital, Sendai, JPN.

|March 27, 2024

Summary

Pegylated granulocyte colony-stimulating factor (G-CSF) can rarely cause aortitis. Discontinuing pegylated G-CSF led to symptom improvement in a breast cancer patient, suggesting it as a potential cause.

Area of Science:

Oncology
Cardiology
Pharmacology

Background:

Pegylated granulocyte colony-stimulating factor (G-CSF) is used to manage chemotherapy-induced neutropenia.

Keywords:

aortitis breast cancer chemotherapy-related toxicity granulocyte colony-stimulating factor large vessel vasculitis

More Related Videos

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Related Experiment Videos

Last Updated: May 1, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Rare cases of aortitis have been linked to pegylated G-CSF treatment.

Aortitis presents with inflammation of the aorta, potentially leading to serious complications.