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Translating knowledge on placebo and nocebo effects into clinical practice.
Elif Buse Caliskan1, Ulrike Bingel1, Angelika Kunkel1
1Department of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Pain Reports
|March 27, 2024
Summary
Treatment expectations, including placebo and nocebo effects, significantly impact health outcomes. Modulating these expectations through contextual factors can optimize therapeutic interventions and improve patient-clinician interactions.
Area of Science:
- Neuroscience
- Psychology
- Clinical Medicine
Background:
- Treatment expectations, encompassing placebo and nocebo effects, are potent modulators of health and treatment outcomes.
- A significant portion of treatment success is attributed to contextual factors influencing patient expectations.
Purpose of the Study:
- To explore the neurobiological basis of treatment expectations.
- To present strategies for modulating contextual factors to enhance treatment outcomes in clinical practice.
Main Methods:
- Selective review of current evidence and clinical practices.
- Alignment with the 2022 IASP Global Year initiative on translating pain knowledge into practice.
Main Results:
- Expectation effects are observed across various conditions, with substantial contributions to pain management.
- Placebo analgesia paradigms demonstrate that treatment effects can stem from expectations rather than solely the intervention.
- Individual variability in response to expectations necessitates further research for personalized strategies.
Conclusions:
- Patient experiences and expectations critically influence treatment efficacy, tolerability, and adherence.
- This review provides insights for clinicians and researchers to enhance patient-clinician interactions by understanding expectation modulation.
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