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Monitoring buprenorphine in patients on medication-assisted treatment
Amadeo Pesce1, Katie Bollman2, Kevin Krock2
1Precision Diagnostics LLC, San Diego, California. ORCID: https://orcid.org/0000-0003-3748-9703.
Background:
Buprenorphine is used for medication-assisted treatment of opioid dependence.
Purpose:
Monitoring of medication adherence involves testing of urine or oral fluid for the drug or its metabolite.
Methods:
Quantitative results using liquid chromatography tandem mass spectrometer testing defined the excretion pattern of the drug and its metabolites.
Results:
Frequency distribution curves of buprenorphine and norbuprenorphine describe the expected drug concentrations of patients on this medication.
Conclusion:
Urine and oral fluid drug testing can be used to monitor adherence in this population.
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